After 22 years, the original Dogfish Head Brewings & Eats pub came down on Monday as an excavator tore into the structure.
Both the Chesapeake & Maine seafood restaurant and the new Brewings & Eats were remained open.
The brewer noted that the demolition revealed that a seafood spot was a former occupant of the property.
The old pub got its start as the smallest commercial brewery in the United States. The company grew steadily and constructed a brewery to Milton. The original location remained the home of a small distillery for a number of years.
Since the original site opened, Dogfish has grown into one of the 20 largest craft brewers in the nation.
In May a new Brewings & Eats opened right next door after a difficult process of gaining approval for the project.
Dogfish faced claims from the city that the property was not grandfathered in regarding a restriction on maximum seating limits for restaurants and bars. Dogfish, riding a wave of support for the project, gained approval.
The original pub will be torn down to make way for a new courtyard tentatively slated to open in Spring 2018.